ORG-25935
IUPAC命名法による物質名
IUPAC名
2-([(1R,2S)-6-Methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-yl]methyl-methylamino)acetic acid
識別
CAS番号
1147011-84-4
ORG-25935は、Organon & Co.（英語版）により開発された薬剤で、グリシントランスポーター1を選択的に阻害する。動物実験では、アルコールの摂取量を減らし、鎮痛および抗けいれん作用、抗精神病薬として研究されており、人に対する臨床試験では解離性麻酔薬であるケタミンの作用を打ち消す効果が示されている[1][2][3][4][5][6][7][8]。
脚注^ “The glycine reuptake inhibitor Org 25935 decreases ethanol intake and preference in male wistar rats”. Alcohol and Alcoholism 42 (1): 11?8. (2006). doi:10.1093/alcalc/agl085. .mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation.cs-ja1 q,.mw-parser-output .citation.cs-ja2 q{quotes:"「""」""『""』"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free a,.mw-parser-output .citation .cs1-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited a,.mw-parser-output .id-lock-registration a,.mw-parser-output .citation .cs1-lock-limited a,.mw-parser-output .citation .cs1-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription a,.mw-parser-output .citation .cs1-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:#d33}.mw-parser-output .cs1-visible-error{color:#d33}.mw-parser-output .cs1-maint{display:none;color:#3a3;margin-left:0.3em}.mw-parser-output .cs1-format{font-size:95%}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}PMID 17098748.
^ “Antinociceptive effects of glycine transporter inhibitors in neuropathic pain models in mice”. Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica 130 (6): 458?63. (December 2007). doi:10.1254/fpj.130.458. PMID 18079595.
^ “The glycine reuptake inhibitor org 25935 interacts with basal and ethanol-induced dopamine release in rat nucleus accumbens”. Alcoholism: Clinical and Experimental Research 33 (7): 1151?7. (July 2009). doi:10.1111/j.1530-0277.2009.00938.x. PMID 19389199.
^ “Glycine transporter 1 (GlyT1) inhibitors exhibit anticonvulsant properties in the rat maximal electroshock threshold (MEST) test”. Brain Research 1331: 105?13. (May 2010). doi:10.1016/j.brainres.2010.03.032. PMID 20303337.
^ “Glycine transporter-1 blockade leads to persistently reduced relapse-like alcohol drinking in rats”. Biological Psychiatry 68 (8): 704?11. (October 2010). doi:10.1016/j.biopsych.2010.05.029. PMID 20655511.
^ “Pre-synaptic glycine GlyT1 transporter--NMDA receptor interaction: relevance to NMDA autoreceptor activation in the presence of Mg2+ ions”. Journal of Neurochemistry 117 (3): 516?27. (May 2011). doi:10.1111/j.1471-4159.2011.07223.x. PMID 21348870.
^ “Differential effects of AMPA receptor potentiators and glycine reuptake inhibitors on antipsychotic efficacy and prefrontal glutamatergic transmission”. Psychopharmacology 221 (1): 115?31. (May 2012). doi:10.1007/s00213-011-2554-3. PMID 22068461.
^ “Glycine transporter inhibitor attenuates the psychotomimetic effects of ketamine in healthy males: preliminary evidence”. Neuropsychopharmacology 37 (4): 1036?46. (March 2012). doi:10.1038/npp.2011.295. PMC 3280648. PMID 22113087. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280648/.
関連項目
統合失調症
グリシン再取り込み阻害薬
グリシントランスポーター1
イクレペルチン
ビトペルチン
ペサンパトル
