NADPH-ヘムタンパク質レダクターゼ
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NADPH-ヘムタンパク質レダクターゼ

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EC番号1.6.2.4
CAS登録番号9023-03-4
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NADPH-ヘムタンパク質レダクターゼ(NADPH-hemoprotein reductase)は、次の化学反応触媒する酸化還元酵素である。NADPH + H+ + 酸化型ヘムタンパク質 ⇌ {\displaystyle \rightleftharpoons } NADP+ + 還元型ヘムタンパク質

反応式の通り、この酵素の基質NADPHとH+と酸化型ヘムタンパク質、生成物はNADP+と還元型ヘムタンパク質である。

組織名はNADPH:hemoprotein oxidoreductaseで、別名にCPR; FAD-cytochrome c reductase; NADP?cytochrome c reductase; NADP?cytochrome reductase; NADPH-dependent cytochrome c reductase; NADPH:P-450 reductase; NADPH:ferrihemoprotein oxidoreductase; NADPH?cytochrome P-450 oxidoreductase; NADPH?cytochrome c oxidoreductase; NADPH?cytochrome c reductase; NADPH?cytochrome p-450 reductase; NADPH?ferricytochrome c oxidoreductase; NADPH?ferrihemoprotein reductase; TPNH2 cytochrome c reductase; TPNH-cytochrome c reductase; aldehyde reductase (NADPH-dependent); cytochrome P-450 reductase; cytochrome c reductase (reduced nicotinamide adenine dinucleotide phosphate, NADPH, NADPH-dependent); dihydroxynicotinamide adenine dinucleotide phosphate-cytochrome c reductase; ferrihemoprotein P-450 reductase; reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase; reductase, cytochrome c (reduced nicotinamide adenine dinucleotide phosphate)がある。
参考文献

Haas E, Horecker BL and Hogness TR (1940). “The enzymatic reduction of cytochrome c, cytochrome c reductase”. J. Biol. Chem. 136: 747–774. 

Horecker BL (1950). “Triphosphopyridine nucleotide-cytochrome c reductase in liver”. J. Biol. Chem. 183: 593–605. 

Lu AY, Junk KW, Coon MJ (1969). “Resolution of the cytochrome P-450-containing omega-hydroxylation system of liver microsomes into three components”. J. Biol. Chem. 244: 3714–21. .mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation.cs-ja1 q,.mw-parser-output .citation.cs-ja2 q{quotes:"「""」""『""』"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free a,.mw-parser-output .citation .cs1-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited a,.mw-parser-output .id-lock-registration a,.mw-parser-output .citation .cs1-lock-limited a,.mw-parser-output .citation .cs1-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription a,.mw-parser-output .citation .cs1-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:#d33}.mw-parser-output .cs1-visible-error{color:#d33}.mw-parser-output .cs1-maint{display:none;color:#3a3;margin-left:0.3em}.mw-parser-output .cs1-format{font-size:95%}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}
PMID 4389465. 

GIBSON QH, PALMER G, WHARTON DC (1965). “STUDIES ON THE MECHANISM OF MICROSOMAL TRIPHOSPHOPYRIDINE NUCLEOTIDE-CYTOCHROME C REDUCTASE”. J. Biol. Chem. 240: 921–31. PMID 14275154. 

WILLIAMS CH Jr, KAMIN H (1962). “Microsomal triphosphopyridine nucleotide-cytochrome c reductase of liver”. J. Biol. Chem. 237: 587–95. PMID 14007123. 

Masters BS, Bilimoria MH, Kamin H, Gibson QH (1965). “The mechanism of 1- and 2-electron transfers catalyzed by reduced triphosphopyridine nucleotide-cytochrome c reductase”. J. Biol. Chem. 240: 4081–8. PMID 4378860. 

Sevrioukova IF, Peterson JA (1995). “NADPH-P-450 reductase: structural and functional comparisons of the eukaryotic and prokaryotic isoforms”. Biochimie. 77: 562–72. doi:10.1016/0300-9084(96)88172-7. PMID 8589067. 

Wang M, Roberts DL, Paschke R, Shea TM, Masters BS, Kim JJ (1997). “Three-dimensional structure of NADPH-cytochrome P450 reductase: prototype for FMN- and FAD-containing enzymes”. Proc. Natl. Acad. Sci. U. S. A. 94: 8411–6. doi:10.1073/pnas.94.16.8411. PMID 9237990. 

Munro AW, Noble MA, Robledo L, Daff SN, Chapman SK (2001). “Determination of the redox properties of human NADPH-cytochrome P450 reductase”. Biochemistry. 40: 1956–63. doi:10.1021/bi001718u. PMID 11329262. 

Munro AW, Noble MA, Robledo L, Daff SN, Chapman SK (2001). “Determination of the redox properties of human NADPH-cytochrome P450 reductase”. Biochemistry. 40: 1956–63. doi:10.1021/bi001718u. PMID 11329262. 

Scrutton NS (2003). “Electron transfer in human cytochrome P450 reductase”. Biochem. Soc. Trans. 31: 497–501. doi:10.1042/BST0310497. PMID 12773143. 

Scrutton NS (2003). “Electron transfer in human cytochrome P450 reductase”. Biochem. Soc. Trans. 31: 497–501. doi:10.1042/BST0310497. PMID 12773143. 


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