HMGB1

PDBに登録されている構造
PDBHuman UniProt検索: RCSB PDBe PDBj

PDBのIDコード一覧

2LY4, 2RTU, 2YRQ


識別子
記号 ⇒HMGB1, HMG1, HMG3, SBP-1, HMG-1, high mobility group box 1, HMGB-1
外部IDOMIM: 163905 HomoloGene: 110676 GeneCards: HMGB1

遺伝子の位置 (ヒト)

染色体13番染色体 (ヒト)[1]

バンドデータ無し開始点30,456,704 bp[1]
終点30,617,597 bp[1]

RNA発現パターン





⇒さらなる参照発現データ

遺伝子オントロジー
分子機能? ⇒DNA-binding transcription factor activity
? ⇒bubble DNA binding
? ⇒DNA polymerase binding
? ⇒C-X-C chemokine binding
? ⇒転写因子結合
? ⇒phosphatidylserine binding
? ⇒リポ多糖結合
? ⇒リアーゼ活性
? ⇒single-stranded DNA binding
? ⇒damaged DNA binding
? ⇒血漿タンパク結合
? ⇒DNA binding, bending
? ⇒supercoiled DNA binding
? ⇒DNA結合
? ⇒four-way junction DNA binding
? ⇒RAGE receptor binding
? ⇒chemoattractant activity
? ⇒RNA結合
? ⇒二本鎖DNA結合
? ⇒double-stranded RNA binding
? ⇒single-stranded RNA binding
? ⇒cytokine activity
? ⇒calcium-dependent protein kinase regulator activity
? ⇒protein kinase activator activity
? ⇒transcription coactivator activity
? ⇒integrin binding

細胞の構成要素? ⇒細胞質
? ⇒エンドソーム
? ⇒膜
? ⇒transcription repressor complex
? ⇒細胞外領域
? ⇒細胞核
? ⇒cell surface
? ⇒細胞膜
? ⇒核質
? ⇒染色体
? ⇒condensed chromosome
? ⇒endoplasmic reticulum-Golgi intermediate compartment
? ⇒secretory granule lumen
? ⇒ficolin-1-rich granule lumen
? ⇒細胞外空間
? ⇒early endosome
? ⇒neuron projection
? ⇒alphav-beta3 integrin-HMGB1 complex

生物学的プロセス? ⇒T-helper 1 cell activation
? ⇒アポトーシスによるDNA断片化
? ⇒adaptive immune response
? ⇒regulation of transcription by RNA polymerase II
? ⇒positive regulation of DNA ligation
? ⇒positive regulation of JNK cascade
? ⇒cellular response to DNA damage stimulus
? ⇒apoptotic cell clearance
? ⇒positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
? ⇒positive regulation of toll-like receptor 9 signaling pathway
? ⇒negative regulation of RNA polymerase II transcription preinitiation complex assembly
? ⇒positive regulation of dendritic cell differentiation
? ⇒positive regulation of DNA binding
? ⇒neuron projection development
? ⇒negative regulation of blood vessel endothelial cell migration
? ⇒positive regulation of interleukin-12 production
? ⇒positive regulation of monocyte chemotaxis
? ⇒activation of innate immune response
? ⇒DNA ligation involved in DNA repair
? ⇒自然免疫
? ⇒炎症反応