FOXO3
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^ “Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor”. Cell 96 (6): 857?68. (Mar 1999). doi:10.1016/S0092-8674(00)80595-4. PMID 10102273. 
^ “Entrez Gene: FOXO3A forkhead box O3A”. 2022年2月12日閲覧。
^ “FOXOs: Signalling Integrators for Homeostasis Maintenance”. Nature Reviews. Molecular Cell Biology 14 (2): 83?97. (Feb 2013). doi:10.1038/nrm3507. PMID 23325358. 
^ “FOXO3a Links Vascular Smooth Muscle Cell Apoptosis, Matrix Breakdown, Atherosclerosis and Vascular Remodeling Through a Novel Pathway Involving MMP13”. Arteriosclerosis, Thrombosis and Vascular Biology 38 (3): 555?565. (Mar 2018). doi:10.1161/ATVBAHA.117.310502. PMC 5828387. PMID 29326312. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828387/. 
^ “The BH3-only protein Puma plays an essential role in cytokine deprivation induced apoptosis of mast cells”. Blood 110 (9): 3209?17. (Nov 2007). doi:10.1182/blood-2007-02-073957. PMC 2200922. PMID 17634411. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2200922/. 
^ “The Akt-regulated forkhead transcription factor FOXO3a controls endothelial cell viability through modulation of the caspase-8 inhibitor FLIP”. The Journal of Biological Chemistry 279 (2): 1513?25. (Jan 2004). doi:10.1074/jbc.M304736200. PMID 14551207. 
^ “FOXO3 promotes quiescence in adult muscle stem cells during the process of self-renewal”. Stem Cell Reports 2 (4): 414?26. (Apr 2014). doi:10.1016/j.stemcr.2014.02.002. PMC 3986584. PMID 24749067. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986584/. 
^ “The emerging roles of forkhead box (Fox) proteins in cancer”. Nature Reviews Cancer 7 (11): 847?59. (Nov 2007). doi:10.1038/nrc2223. PMID 17943136. 
^ “Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor”. Science 339 (6116): 211?214. (2013). Bibcode: 2013Sci...339..211S. doi:10.1126/science.1227166. PMC 3735349. PMID 23223453. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735349/. 
^ “The neuropharmacology of the ketogenic diet”. Pediatric Neurology 36 (5): 281?292. (2007). doi:10.1016/j.pediatrneurol.2007.02.008. PMC 1940242. PMID 17509459. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1940242/. 
^ “Multivariate genomic scan implicates novel loci and haem metabolism in human ageing”. Nature Communications 11 (1): 3570. (July 2020). Bibcode: 2020NatCo..11.3570T. doi:10.1038/s41467-020-17312-3. PMC 7366647. PMID 32678081. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366647/. 
^ “FOXO3A genotype is strongly associated with human longevity”. Proceedings of the National Academy of Sciences of the United States of America 105 (37): 13987?92. (Sep 2008). Bibcode: 2008PNAS..10513987W. doi:10.1073/pnas.0801030105. PMC 2544566. PMID 18765803. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2544566/. 
^ “Association of FOXO3A variation with human longevity confirmed in German centenarians”. Proceedings of the National Academy of Sciences of the United States of America 106 (8): 2700?5. (Feb 2009). Bibcode: 2009PNAS..106.2700F. doi:10.1073/pnas.0809594106. PMC 2650329. PMID 19196970. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2650329/. 



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“The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2”. Journal of Immunology 168 (10): 5024?5031. (May 2002).
doi:10.4049/jimmunol.168.10.5024. PMID 11994454. 

“FOXO3: A Major Gene for Human Longevity ? A Mini-Review”. Gerontology 61 (6): 515?25. (Mar 2015). doi:10.1159/000375235. PMC 5403515. PMID 25832544. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403515/. 

“Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome?”. Annals of the New York Academy of Sciences 1024 (1): 153?67. (Jun 2004). Bibcode: 2004NYASA1024..153K. doi:10.1196/annals.1321.013. PMID 15265780. https://zenodo.org/record/1235880. 

“AF6q21, a novel partner of the MLL gene in t(6;11)(q21;q23), defines a forkhead transcriptional factor subfamily”. Blood 90 (9): 3714?9. (Nov 1997). doi:10.1182/blood.V90.9.3714. PMID 9345057. 

“Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily”. Genomics 47 (2): 187?99. (Jan 1998). doi:10.1006/geno.1997.5122. PMID 9479491. 

“Molecular cloning of FKHRL1P2, a member of the developmentally regulated fork head domain transcription factor family”. Gene 221 (1): 135?42. (Oct 1998). doi:10.1016/S0378-1119(98)00441-7. PMID 9852958. 

“Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor”. Cell 96 (6): 857?68. (Mar 1999). doi:10.1016/S0092-8674(00)80595-4. PMID 10102273. 

“AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1”. Nature 404 (6779): 782?7. (Apr 2000). Bibcode: 2000Natur.404..782M. doi:10.1038/35008115. PMID 10783894. 

“Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)”. Molecular and Cellular Biology 21 (3): 952?65. (Feb 2001). doi:10.1128/MCB.21.3.952-965.2001. PMC 86685. PMID 11154281. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC86685/. 

“Ligand-dependent interaction of estrogen receptor-alpha with members of the forkhead transcription factor family”. The Journal of Biological Chemistry 276 (36): 33554?60. (Sep 2001). doi:10.1074/jbc.M105555200. PMID 11435445. 

“Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors”. Molecular and Cellular Biology 22 (7): 2025?36. (Apr 2002). doi:10.1128/MCB.22.7.2025-2036.2002. PMC 133681. PMID 11884591. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC133681/. 

“Phosphorylation of forkhead transcription factors by erythropoietin and stem cell factor prevents acetylation and their interaction with coactivator p300 in erythroid progenitor cells”. Oncogene 21 (10): 1556?62. (Feb 2002). doi:10.1038/sj.onc.1205230. PMID 11896584. 

“Down-regulation of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by insulin: the role of the forkhead transcription factor FKHRL1”. The Biochemical Journal 366 (Pt 1): 289?97. (Aug 2002). doi:10.1042/BJ20020598. PMC 1222772. PMID 12027802. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1222772/. 

“Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants”. Molecular Vision 8: 205?20. (Jun 2002). PMID 12107410. 

“FOXO proteins regulate tumor necrosis factor-related apoptosis inducing ligand expression. Implications for PTEN mutation in prostate cancer”. The Journal of Biological Chemistry 277 (49): 47928?37. (Dec 2002). doi:10.1074/jbc.M207509200. PMID 12351634. 

“Proteolytic regulation of Forkhead transcription factor FOXO3a by caspase-3-like proteases”. Oncogene 22 (29): 4557?68. (Jul 2003). doi:10.1038/sj.onc.1206778. PMID 12881712. 

“Neutrophil activation by fMLP regulates FOXO (forkhead) transcription factors by multiple pathways, one of which includes the binding of FOXO to the survival factor Mcl-1”. Journal of Leukocyte Biology 74 (4): 583?92. (Oct 2003). doi:10.1189/jlb.0103020. PMID 12960271. 

“FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines”. The Journal of Biological Chemistry 278 (50): 49795?805. (Dec 2003). doi:10.1074/jbc.M309523200. PMID 14527951. 

“FOXO3a Links Vascular Smooth Muscle Cell Apoptosis, Matrix Breakdown, Atherosclerosis and Vascular Remodeling Through a Novel Pathway Involving MMP13”. Arteriosclerosis, Thrombosis and Vascular Biology 38 (3): 555?565. (Mar 2018). doi:10.1161/ATVBAHA.117.310502. PMC 5828387. PMID 29326312. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828387/. 

“The Akt-regulated forkhead transcription factor FOXO3a controls endothelial cell viability through modulation of the caspase-8 inhibitor FLIP”. The Journal of Biological Chemistry 279 (2): 1513?25. (Jan 2004). doi:10.1074/jbc.M304736200. PMID 14551207. 

“Regulation of sterol carrier protein gene expression by the forkhead transcription factor FOXO3a”. Journal of Lipid Research 45 (1): 81?8. (Jan 2004). doi:10.1194/jlr.M300111-JLR200. PMID 14563822. 

関連項目

フォークヘッドボックスタンパク質

Daf-16(英語版)

外部リンク

FOXO3A protein, human
- MeSHアメリカ国立医学図書館・生命科学用語シソーラス(英語)


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