また、CD14はTLR4のみならずTLR2やTLR3のリガンド結合にも関わる[8]。TLRのシグナル経路。灰色の点線は未知の経路を示す。 CD14は単球、マクロファージ、顆粒球などの骨髄系細胞に発現している[8]。
組織分布
脚注^ Setoguchi M, Nasu N, Yoshida S, Higuchi Y, Akizuki S, Yamamoto S (July 1989). “Mouse and human CD14 (myeloid cell-specific leucine-rich glycoprotein) primary structure deduced from cDNA clones”. Biochim. Biophys. Acta 1008 (2): 213?22. doi:10.1016/0167-4781(80)90012-3
^ Simmons DL, Tan S, Tenen DG, Nicholson-Weller A, Seed B (1 January 1989). ⇒“Monocyte antigen CD14 is a phospholipid anchored membrane protein”. Blood 73 (1): 284?9. PMID 2462937. ⇒http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=2462937.
^ Kirkland TN, Viriyakosol S (1998). “Structure-function analysis of soluble and membrane-bound CD14”. Prog. Clin. Biol. Res. 397: 79?87. PMID 9575549.
^ Kelley SL, Lukk T, Nair SK, Tapping, RI (2013). ⇒“The Crystal Structure of Human Soluble CD14 Reveals a Bent Solenoid with a Hydrophobic Amino-Terminal Pocket”. J. Immunol. 190 (3): 1304-1311. doi:10.4049/jimmunol.1202446. PMID 23264655. ⇒http://www.jimmunol.org/content/190/3/1304.long.
^ Kitchens RL (2000). “Role of CD14 in cellular recognition of bacterial lipopolysaccharides”. Chem. Immunol.. Chemical Immunology and Allergy 74: 61?82. doi:10.1159/000058750. ISBN 3-8055-6917-3. PMID 10608082.
^ Tapping RI, Tobias PS (2000). “Soluble CD14-mediated cellular responses to lipopolysaccharide”. Chem. Immunol.. Chemical Immunology and Allergy 74: 108?21. doi:10.1159/000058751. ISBN 3-8055-6917-3. PMID 10608084.
^ Ranoa DR, Kelley SL, Tapping RI (2013). “Human LBP and CD14 independently deliver triacylated lipoproteins to TLR1 and TLR2 and enhance formation of the ternary signaling complex.”. J. Biol. Chem. 74 (epub): epub. doi:10.1074/jbc.M113.453266. PMID 23430250.
^ a b 矢田純一『医系免疫学』(改訂11版)、2009年。ISBN 978-4-498-10602-4。
外部リンク
CD14 Antigens - MeSH・アメリカ国立医学図書館・生命科学用語シソーラス(英語)
⇒ThermoFishser.com
⇒ThermoFishser.com
⇒The Journal of Immunology
⇒[1][リンク切れ]
参考文献
Todd RF, Petty HR (1997). “Beta 2 (CD11/CD18) integrins can serve as signaling partners for other leukocyte receptors”. J. Lab. Clin. Med. 129 (5): 492?8. doi:10.1016/S0022-2143(97)90003-2. PMID 9142045.
Kelley SL, Lukk T, Nair SK, Tapping RI (2013). “The Crystal Structure of Human Soluble CD14 Reveals a Bent Solenoid with a Hydrophobic Amino-Terminal Pocket”. J.Immunol. 190 (3): 1304-1311. doi:10.4049/jimmunol.1202446. PMID 23264655.
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