3-イソプロピルリンゴ酸デヒドラターゼ
識別子
EC番号4.2.1.33
CAS登録番号37290-72-5
データベース
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAM ⇒profile
PDB構造RCSB PDB PDBj PDBe PDBsum
遺伝子オントロジー ⇒AmiGO / QuickGO

検索
PMCarticles
PubMedarticles
NCBIproteins

テンプレートを表示

3-イソプロピルリンゴ酸デヒドラターゼ(3-Isopropylmalate dehydratase、EC 4.2.1.33)は、ロイシンの生合成の過程で、脱水により2-イソプロピルリンゴ酸から3-イソプロピルリンゴ酸への異性化を触媒するアコニターゼのホモログである[1][2][3]。
出典^ Gross SR, Burns RO, Umbarger HE (1963). “The biosynthesis of leucine. II. The enzymic isomerization of beta-carboxy-beta-hydroxyisocaproate and alpha-hydroxy-beta-carboxyisocaproate”. Biochemistry 2 (5): 1046?52. doi:10.1021/bi00905a023. .mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation.cs-ja1 q,.mw-parser-output .citation.cs-ja2 q{quotes:"「""」""『""』"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free a,.mw-parser-output .citation .cs1-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited a,.mw-parser-output .id-lock-registration a,.mw-parser-output .citation .cs1-lock-limited a,.mw-parser-output .citation .cs1-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription a,.mw-parser-output .citation .cs1-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:#d33}.mw-parser-output .cs1-visible-error{color:#d33}.mw-parser-output .cs1-maint{display:none;color:#3a3;margin-left:0.3em}.mw-parser-output .cs1-format{font-size:95%}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}PMID 14087357. 
^ Calvo JM, Stevens CM, Kalyanpur MG, Umbarger HE (December 1964). “The absolute configuration of alpha-hydroxy-beta-carboxyisocaproic acid (3-isopropylmalic acid), an intermediate in leucine biosynthesis”. Biochemistry 3 (12): 2024?7. doi:10.1021/bi00900a043. PMID 14269331. 
^ Cole FE, Kalyanpur MG, Stevens CM (August 1973). “Absolute configuration of alpha isopropylmalate and the mechanism of its conversion to beta isopropylmalate in the biosynthesis of leucine”. Biochemistry 12 (17): 3346?50. doi:10.1021/bi00741a031. PMID 4270046. 

外部リンク

3-isopropylmalate dehydratase - MeSH・アメリカ国立医学図書館・生命科学用語シソーラス（英語）