CASP8

PDBに登録されている構造
PDBオルソログ検索: RCSB PDBe PDBj

PDBのIDコード一覧

1F9E, 1I4E, 1QDU, 1QTN, 2C2Z, 2FUN, 2K7Z, 2Y1L, 3H11, 3KJN, 3KJQ, 4JJ7, 4PRZ, 4PS1, 4ZBW


識別子
記号 ⇒CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5, caspase 8
外部IDOMIM: 601763 MGI: ⇒1261423 HomoloGene: 7657 GeneCards: CASP8

遺伝子の位置 (ヒト)

染色体2番染色体 (ヒト)[1]

バンドデータ無し開始点201,233,443 bp[1]
終点201,287,711 bp[1]

遺伝子の位置 (マウス)

染色体1番染色体 (マウス)[2]

バンドデータ無し開始点58,834,533 bp[2]
終点58,886,662 bp[2]

RNA発現パターン



⇒さらなる参照発現データ

遺伝子オントロジー
分子機能? ⇒death effector domain binding
? ⇒cysteine-type peptidase activity
? ⇒cysteine-type endopeptidase activity involved in apoptotic signaling pathway
? ⇒scaffold protein binding
? ⇒血漿タンパク結合
? ⇒identical protein binding
? ⇒cysteine-type endopeptidase activity involved in apoptotic process
? ⇒cysteine-type endopeptidase activity
? ⇒加水分解酵素活性
? ⇒ubiquitin protein ligase binding
? ⇒ペプチダーゼ活性
? ⇒cysteine-type endopeptidase activity involved in execution phase of apoptosis
? ⇒death receptor binding
? ⇒tumor necrosis factor receptor binding
? ⇒protein-containing complex binding

細胞の構成要素? ⇒cell body
? ⇒細胞質基質
? ⇒CD95 death-inducing signaling complex
? ⇒ripoptosome
? ⇒核質
? ⇒ミトコンドリア外膜
? ⇒細胞死誘導シグナル伝達複合体
? ⇒脂質ラフト
? ⇒neuron projection
? ⇒細胞骨格
? ⇒細胞質
? ⇒ミトコンドリア
? ⇒細胞核
? ⇒高分子複合体

生物学的プロセス? ⇒regulation of apoptotic process
? ⇒エストラジオールへの反応
? ⇒activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
? ⇒response to antibiotic
? ⇒regulation of tumor necrosis factor-mediated signaling pathway
? ⇒positive regulation of macrophage differentiation
? ⇒cellular response to organic cyclic compound
? ⇒natural killer cell activation
? ⇒negative regulation of I-kappaB kinase/NF-kappaB signaling
? ⇒TRAIL-activated apoptotic signaling pathway
? ⇒タンパク質分解
? ⇒macrophage differentiation
? ⇒TRIF-dependent toll-like receptor signaling pathway
? ⇒response to tumor necrosis factor
? ⇒B cell activation
? ⇒細胞表面受容体シグナル伝達経路
? ⇒リポ多糖への反応
? ⇒cellular response to mechanical stimulus
? ⇒activation of cysteine-type endopeptidase activity
? ⇒positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
? ⇒death-inducing signaling complex assembly
? ⇒positive regulation of proteolysis